[HTML][HTML] T cell depletion increases humoral response by favoring T follicular helper cells expansion
RB Gassen, TJ Borges, MJ Pérez-Sáez… - American Journal of …, 2022 - Elsevier
Antibody-mediated rejection is a major cause of long-term graft loss in kidney transplant
patients. T follicular helper (Tfh) cells are crucial for assisting B cell differentiation and are
required for an efficient antibody response. Anti-thymocyte globulin (ATG) is a widely used
lymphocyte-depleting induction therapy. However, less is known about how ATG affects Tfh
cell development and donor-specific antibody (DSA) formation. We observed an increase in
circulating Tfh cells at 6 months after kidney transplant in patients who received ATG. Using …
patients. T follicular helper (Tfh) cells are crucial for assisting B cell differentiation and are
required for an efficient antibody response. Anti-thymocyte globulin (ATG) is a widely used
lymphocyte-depleting induction therapy. However, less is known about how ATG affects Tfh
cell development and donor-specific antibody (DSA) formation. We observed an increase in
circulating Tfh cells at 6 months after kidney transplant in patients who received ATG. Using …
