Novel broad-spectrum chemokine inhibitor protects against lung ischemia-reperfusion injury
BV Naidu, AS Farivar, SM Woolley, D Grainger… - The Journal of heart and …, 2004 - Elsevier
Background: Functional roles for chemokines have been demonstrated in several models of
ischemia-reperfusion injury. The redundancy inherent to chemokine pathways makes
administration of neutralizing antibodies to any single chemokine ineffective in ameliorating
injury. This study was undertaken to define the pattern of chemokine expression in lung
ischemia-reperfusion injury (LIRI), and to determine whether a broad-spectrum chemokine
inhibitor, NR58-3.14. 3, could confer significant protection against LIRI. Methods: Left lungs …
ischemia-reperfusion injury. The redundancy inherent to chemokine pathways makes
administration of neutralizing antibodies to any single chemokine ineffective in ameliorating
injury. This study was undertaken to define the pattern of chemokine expression in lung
ischemia-reperfusion injury (LIRI), and to determine whether a broad-spectrum chemokine
inhibitor, NR58-3.14. 3, could confer significant protection against LIRI. Methods: Left lungs …
