Cellular senescence in the cholangiopathies
PS Bogert, SP O'Hara, NF LaRusso - Current opinion in …, 2022 - journals.lww.com
PS Bogert, SP O'Hara, NF LaRusso
Current opinion in gastroenterology, 2022•journals.lww.comCholangiopathies present unique and divergent clinicopathological features, causes and
genetic backgrounds, but share several common disease processes. Cholangiocyte
senescence in the cholestatic cholangiopathies, primarily PSC and PBC, is regarded as a
key pathogenetic process. Importantly, senescent cholangiocytes exhibit phenotypic
features including the senescence-associated secretory phenotype (SASP) and resistance
to apoptosis that provide new directions for basic research and new prognostic and …
genetic backgrounds, but share several common disease processes. Cholangiocyte
senescence in the cholestatic cholangiopathies, primarily PSC and PBC, is regarded as a
key pathogenetic process. Importantly, senescent cholangiocytes exhibit phenotypic
features including the senescence-associated secretory phenotype (SASP) and resistance
to apoptosis that provide new directions for basic research and new prognostic and …
Summary
Cholangiopathies present unique and divergent clinicopathological features, causes and genetic backgrounds, but share several common disease processes. Cholangiocyte senescence in the cholestatic cholangiopathies, primarily PSC and PBC, is regarded as a key pathogenetic process. Importantly, senescent cholangiocytes exhibit phenotypic features including the senescence-associated secretory phenotype (SASP) and resistance to apoptosis that provide new directions for basic research and new prognostic and therapeutic approaches for clinical practice.
Lippincott Williams & Wilkins